Stage 4 ovarian cancer

The stage of a cancer tells the doctor how big it is and if it has spread. The tests and scans you have to diagnose your cancer will give some information about the stage. But your doctor might not be able to tell you the exact stage until you have surgery.

Doctors use the International Federation of Gynecology and Obstetrics (FIGO) staging system to stage cancers in the:  

  • ovaries 
  • fallopian tubes
  • peritoneum

There are four stages, numbered 1 to 4. 

Stage 4 ovarian cancer has spread to other parts of your body organs such as the liver or lungs. The main treatments are chemotherapy and surgery. 

What is stage 4 ovarian cancer?

Stage 4 ovarian cancer has spread to distant body part such as the liver or lungs. 

It is divided into 2 groups:

Stage 4a means the cancer has caused a build up of fluid in the lining of the lungs (the pleura). This is called a malignant pleural effusion.

Diagram showing stage 4A ovarian cancer

Stage 4b means the cancer has spread to:

  • the inside of the liver or spleen
  • lymph nodes Open a glossary item outside the tummy (abdomen)
  • other organs such as the lungs
Diagram showing stage 4B ovarian cancer

Treating stage 4 ovarian cancer

Treatments for stage 4 ovarian cancer include:

  • surgery  
  • chemotherapy
  • targeted cancer drugs 
  • radiotherapy

Your healthcare team consider several factors when deciding what treatment you need. These include:

  • where the cancer has spread to
  • whether the specialist surgeon (gynaecological oncologist) thinks they can remove all the cancer 
  • your general health

Surgery

Your specialist surgeon (gynaecological oncologist) will remove:

  • both ovaries
  • fallopian tubes
  • your womb (including the cervix)

They will also check where the cancer has spread to in your pelvis and if it is in your lymph nodes. Your gynaecological oncologist will aim to remove as much of the cancer as possible. 

This is called cytoreductive surgery. You may also hear it called debulking surgery.

Chemotherapy

You might have:

  • chemotherapy after surgery – this is called adjuvant chemotherapy with cytoreductive surgery
  • chemotherapy before and after surgery – this is called neoadjuvant chemotherapy with interval cytoreductive surgery
  • chemotherapy into your abdomen during surgery – this is called hyperthermic intraperitoneal chemotherapy or HIPEC

Your healthcare team will discuss the best treatment for you. When you have chemotherapy will depend on your individual case.

Targeted cancer drugs

Some people may have treatment with a targeted cancer drug. This will depend on your situation. You might have a targeted cancer drug:

  • with chemotherapy
  • on its own after chemotherapy

If you can't have surgery

It might not be possible to have surgery if your cancer has spread widely or you are not well enough.

You may have chemotherapy on its own to shrink the cancer as much as possible and to slow its growth.

You might have other treatments to help relieve your symptoms. This could be treatment for fluid in the abdomen (ascites) or for a blocked bowel. Or radiotherapy to relieve symptoms like pain.

About other stages

  • Cancer of the ovary, fallopian tube, and peritoneum: 2021 update
    JS Berek and others
    International Journal of Gynecology and Obstetrics, 2021. Volume 155. Pages 61-85

  • British Gynaecological Cancer Society (BGCS) ovarian, tubal and primary peritoneal cancer guidelines: Recommendations for practice update 2024
    E Moss and others
    European Journal of Obstetrics & Gynecology and Reproductive Biology, 2024. Volume 300. Pages 69-123

  • Ovarian cancer: recognition and initial management
    National Institute for Health and Care Excellence (NICE), April 2011 (updated 2023)

  • Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO clinical practice guideline for diagnosis, treatment and follow up
    A Gonzalez-Martin and others
    Annals of oncology, 2023. Volume 34. Pages 833 – 848

  • Non-epithelial ovarian cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    I Ray-Coquard and others
    Annals of Oncology, 2018, Volume 29. Pages iv1-iv18

  • The information on this page is based on literature searches and specialist checking. We used many references and there are too many to list here. Please contact patientinformation@cancer.org.uk if you would like to see the full list of references we used for this information.

Last reviewed: 
02 Dec 2024
Next review due: 
02 Dec 2027

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