What are the different types of brain tumours in children?

There are over 100 different types of tumour that can develop in the brain or central nervous system.

Brain tumours can start in any part of the brain or spinal cord (primary brain tumours). Or cancer can spread to the brain or spinal cord from somewhere else in the body. This is known as a secondary brain tumour or brain metastases. Secondary brain tumours are much less common in children than adults.

The names of the different types of brain tumours are based on:

  • the type of cell they develop from
  • the area of the brain they are growing in
  • the genetic changes found in the tumour. A doctor might call these gene changes a biomarker or molecular marker
  • whether it mostly develops in children or adults

Types of brain tumours

The most common types of brain tumours in children are:

  • astrocytoma (glioma)
  • ependymoma
  • medulloblastoma

There are many other types, including:

  • germ cell tumours
  • choroid plexus tumours
  • embryonal tumours with multi layered rosettes
  • craniopharyngiomas
  • atypical teratoid rhabdoid tumour
  • pineoblastoma

Astrocytoma (Glioma)

Astrocytomas are a type of brain tumour also called a glioma. This is because they develop from a type of glial cell called an astrocyte. They can develop anywhere in the brain.

Most astrocytomas in children are low grade. This means the tumour cells look similar to normal cells. The tumours grow fairly slowly and are less likely to spread. Less commonly the astrocytoma is high grade. These tumours tend to grow more quickly and are more likely to spread to other areas of the brain or spine. It is extremely rare that they spread to other areas of the body.

Astrocytomas are the most common type of brain and spinal cord tumours in children. Around 175 children are diagnosed with an astrocytoma each year in the UK.

The most common subtype of astrocytoma is pilocytic astrocytoma. It is a type of low grade glioma. Around 90 children are diagnosed with this type each year.

Optic pathway gliomas (OPGs)

These are tumours that develop on the nerves that carry information from the eye through the brain. They are mostly pilocytic astrocytomas. Children with the genetic condition neurofibromatosis type 1 Open a glossary item most commonly develop this type of tumour.

These types of tumours are usually slow growing and cause changes to your child’s vision. 

Diffuse midline glioma

Diffuse midline glioma used to be called diffuse intrinsic pontine glioma (DIPG). It may also be called a brainstem glioma.

These tumours contain a known genetic change called the biomarker H3 K27M mutation.

Diffuse midline gliomas are high grade and grow quickly. This means symptoms develop quickly. 

Surgery is not usually possible for these tumours. This is because the tumour is in such a delicate and important area of the brain. Doctors usually use radiotherapy to treat them. Researchers are looking into how they can improve the diagnosis and treatment of children with these types of tumours.

Ependymomas

Ependymomas usually start from ependymal cells. These cells line the fluid filled areas of the brain (ventricles) and the spinal cord. Their job is to repair any damaged nerve tissue. 

They are most common in young infants, aged up to 5 years. Around 30 children are diagnosed with ependymoma every year in the UK.

Embryonal tumours

These types of tumours develop from cells left over from early development in the womb.
All embryonal tumours are grade 4. This means they are high grade (malignant).

There are several different types of embryonal tumours. Each type can be further divided into subtypes. This is based on their genetic and molecular information. Some of the main types include:

  • medulloblastoma
  • embryonal tumours with multi layered rosettes (ETMR)
  • atypical teratoid rhabdoid tumour (ATRT)
  • pineoblastoma

Here is an overview of some of them:

Medulloblastoma

Medulloblastoma is the most common cancerous (malignant) brain tumour in children. Adults can also get this type of tumour, but it is rare. These types of brain tumours are high grade because:

  • the tumour often grows quickly
  • they can spread to other areas of the brain and spinal cord

Medulloblastomas develop at the back of the brain in the cerebellum.

Doctors used to talk about medulloblastoma as a primitive neuro ectodermal tumour (PNET). This term is no longer used.

Embryonal tumours with multi layered rosettes (ETMR)

Embryonal tumours with multi layered rosettes are a group of rare embryonal tumours. They’re grouped together because of what they look like under the microscope. These types of tumours can develop in different parts of the brain.

ETMR tumours are high grade and usually affect children up to the age of 3 years old.

The main treatments for ETMRs are:

  • chemotherapy
  • surgery
  • radiotherapy

Atypical teratoid rhabdoid tumour (ATRT)

These tumours are another type of rare embryonal tumour. The majority of these occur in children under 3 years of age. Very rarely they can occur in adults.

These tumours tend to be fast growing (high grade). They can develop in different parts of the brain.

The main treatments for ATRT include:

  • surgery
  • chemotherapy
  • high dose chemotherapy followed by an autologous stem cell transplant Open a glossary item
  • radiotherapy

Pineoblastoma

Pineoblastoma is a rare type of embryonal tumour. It mainly affects children in the first 2 years of life, but can happen at any age. These are high grade tumours that start in the pineal gland Open a glossary item. The pineal gland is in the centre of the brain.

The pineal gland’s main known job is to control your sleep pattern. So it makes the hormone serotonin in the day and then changes it into the hormone melatonin at night.

Doctors treat these tumours with a combination of:

  • surgery
  • chemotherapy
  • radiotherapy

Craniopharyngioma

Craniopharyngiomas (pronounced cran-ee-oh-fah-rin-gee-oh-mahs) are very rare brain tumours. There are 2 different types:

  • adamantinous craniopharyngioma (ACP)
  • papillary craniopharyngioma (PCP)

Adamantinous craniopharyngioma (ACP) are mostly found in children and teenagers. They can also occur in adults but this is less common. Papillary craniopharyngioma mainly occurs in adults.

Craniopharyngiomas are low grade tumours. This means that they are slow growing. Craniopharyngiomas do not usually spread. 

These tumours usually grow near the base of the brain, just above the pituitary gland Open a glossary item.

Diagram showing a craniopharyngioma tumour

They develop close to important structures in the brain and can cause problems as they grow. They can cause changes in hormone levels and problems with eyesight.

Doctors usually treat craniopharyngioma with surgery and, if necessary, radiotherapy.

We have more information about craniopharyngioma. This information is for people of all ages with this type of tumour. Remember to click back to the children’s brain tumour section to learn more about:

  • diagnosis
  • treatment
  • support for children and families

Germ cell tumours

Germ cell tumours are very rare in children. They are more common in teenagers and young adults. They grow from cells left over from the earliest development of the body in the womb. Normally these cells are harmless, but some can start to grow out of control.

There are two main groups of germ cell tumours. They are:

  • non germinomatous germ cell tumours (NGGCT) or secreting germ cell tumours
  • germinomas or non secreting germ cell tumours

There are many sub types of secreting germ cell tumours. These tumours make higher than normal amounts of substances that can show up in the blood or cerebrospinal fluid (CSF). These substances are tumour markers.

Your child might have a blood test or lumbar puncture if the doctor thinks they may have a secreting germ cell tumour. They look for tumour markers such as:

  • alpha fetoprotein (AFP)
  • beta human choriogonadotropin (beta HCG)

Germinomas or non secreting germ cell tumours don’t make the tumour marker AFP. But some do make slightly more than normal levels of the substance HCG. Doctors often diagnose these tumours from the biopsy.

Treatment for secreting germ cell tumours

The main treatments for germ cell tumours that secrete tumour markers are:

  • chemotherapy
  • radiotherapy

Your child might have surgery after chemotherapy and radiotherapy, but this is rare.

Treatment for non secreting germ cell tumours or germinomas

Germinomas generally respond well to radiotherapy and chemotherapy. Because of this, doctors are trying to reduce the amount of radiotherapy they give to children and young people with germinomas. They hope this will help reduce the long term effects of brain tumour treatment.

Choroid plexus tumours

The choroid plexus is a network of blood vessels and cells. Its main job is to make cerebrospinal fluid. 

These tumours are rare. They mainly affect children, but they can also affect teenagers and adults.

There are 3 subtypes of choroid plexus tumours. These are:

  • choroid plexus papilloma
  • atypical choroid plexus papilloma
  • choroid plexus carcinoma

Choroid plexus papilloma is the most common of the 3 types.

Each year in the UK around 7 children are diagnosed with choroid plexus papilloma. Around 4 children are diagnosed with choroid plexus carcinoma.

Treatment for each type of choroid plexus tumour is different. Most children with a choroid plexus papilloma only have surgery. Sometimes they might have other treatment beforehand such as chemotherapy. Children with atypical choroid plexus papilloma usually have surgery and chemotherapy.

Children who have choroid plexus carcinoma have surgery and chemotherapy, and some might have radiotherapy as well.

Some children with these tumours might have arterial embolisation Open a glossary item to lower the risk of blood loss during surgery.

Spinal cord tumours

Children might develop a tumour in their spinal cord. These tumours are grouped together because they develop in the spine. But there are different types depending on the type of cell the tumour started in. Some of the types include:

  • astrocytomas
  • ependymomas
  • gangliomas
  • ATRT
  • germ cell tumours

Doctors treat these tumours with a combination of:

  • radiotherapy
  • chemotherapy
  • surgery

What next?

We have detailed information about:

  • astrocytoma

  • medulloblastoma

  • ependymoma

If your child has been diagnosed with another type of brain tumour you might find our general information on tests, treatment and support helpful.

  • Brain and other central nervous system tumor statistics, 2021
    K D Miller and others
    A Cancer Journal for Clinicians, 2021. Volume 71, Issue 5, Pages 381 to 406

  • The 2021 WHO Classification of Tumours of the Central Nervous System: a summary
    D N Louis and others
    Neuro-Oncology, 2021. Volume 23, Issue 8, Pages 1231 to 1251

  • Children, teenagers and young adults UK cancer statistics report 2021
    Public Health England (PHE), 2021

  • Brain Tumours in children
    A Gajjar and others
    Springer, 2018

  • Brain and Spinal Tumors in childhood (2nd Edition)
    D A Walker and others
    Taylor and Francis Group, 2020

  • The information on this page is based on literature searches and specialist checking. We used many references and there are too many to list here. Please contact patientinformation@cancer.org.uk with details of the particular issue you are interested in if you need additional references for this information.

Last reviewed: 
03 Jan 2023
Next review due: 
03 Jan 2026

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