Trabectedin (Yondelis)
Trabectedin is a type of chemotherapy drug. It is pronounced trab-ec-tih-din. It is also called Yondelis.
It is a treatment for soft tissue sarcoma that has spread to other parts of the body (advanced cancer). It is for people who have already had treatment with, or are unable to have, ifosfamide and an anthracycline chemotherapy such as doxorubicin.
How does trabectedin work?
Trabectedin works by sticking to the in cells and damaging it. This stops the cancer cells growing and multiplying.
How do you have trabectedin?
You have trabectedin into your bloodstream (intravenously).
You might have treatment through a long plastic tube that goes into a large vein in your chest. The tube stays in place throughout the course of treatment. This can be a:
- central line
- PICC line
- portacath
If you don't have a central line
You might have treatment through a thin short tube (a cannula) that goes into a vein in your arm. You have a new cannula each time you have treatment.
Risk of tissue damage
When you are having this treatment through a cannula it could damage the tissue if they leak out of the vein. This is called extravasation. This can happen anywhere along the vein that the drug is going into. It doesn’t happen very often. Tell your nurse straight away if you notice any changes such as swelling, redness, pain, burning, or a stinging feeling.
Your nurse will stop the drug treatment. And they will treat the area to relieve symptoms and reduce tissue damage. Contact your healthcare team if you develop any of these symptoms when you are at home.
How often do you have trabectedin?
You have trabectedin as cycles of treatment. This means that you have the drug and then a rest to allow your body to recover.
Each cycle of treatment lasts 21 days (3 weeks). You usually continue to have trabectedin for as long as it is working, and the side effects aren’t too bad.
- You have trabectedin through a drip over 24 hours.
- Your nurse disconnects your drip.
- You have no treatment.
You then start your next cycle of treatment.
You might have a drug called granulocyte colony stimulating factor (G-CSF) after your chemotherapy. This is to help your white blood cells recover after chemotherapy. It helps lower your risk of getting an infection after having this treatment.
Tests
You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
You usually have weekly bloods for the first 6 weeks of this treatment. This gradually gets less often.
Before treatment starts you may have a blood test to check for viruses such as hepatitis B, hepatitis C, and . This is called a viral screen.
It’s important for your doctor to know if you have had any of these viruses. This is because this treatment can weaken your and can cause the virus to become active again (reactivation).
You might also have a scan of your heart before and during your treatment. This is called an echocardiogram or .
What are the side effects of trabectedin?
Side effects can vary from person to person. They also depend on what other treatments you're having.
When to contact your team
Your doctor, nurse or pharmacist will go through the possible side effects. They will monitor you during treatment and check how you are at your appointments. Contact your advice line as soon as possible if:
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you have severe side effects
-
your side effects aren’t getting any better
-
your side effects are getting worse
Early treatment can help manage side effects better.
Contact your advice line immediately if you have signs of infection, including a temperature above 37.5C or below 36C.
We haven't listed all the side effects here. Talk to your healthcare team if you have any new symptoms that you think might be a side effect of your treatment.
Remember it is very unlikely that you will have all of these side effects. But you might have some of them at the same time.
Common side effects
These side effects happen in more than 10 in 100 people (more than 10%). You might have one or more of them. They include:
Increased risk of getting an infection
Increased risk of getting an infection is due to a drop in white blood cells. Symptoms include a change in temperature, aching muscles, cough, headaches, feeling cold and shivery, pain or a burning feeling when weeing, or generally feeling unwell. You might have other symptoms depending on where the infection is.
Infections can sometimes be life threatening. You should contact your advice line urgently if you think you have an infection.
Breathlessness and looking pale
You might be breathless and look pale due to a drop in red blood cells. This is called anaemia.
Bruising, bleeding gums or nosebleeds
This is due to a drop in the number of platelets in your blood. These blood cells help the blood to clot when we cut ourselves. You may have nosebleeds or bleeding gums after brushing your teeth. Or you may have lots of tiny red spots or bruises on your arms or legs (known as petechiae).
Tiredness and weakness (fatigue)
Tiredness and weakness (fatigue) can happen during and after treatment. Doing gentle exercises each day can keep your energy up. Don't push yourself, rest when you start to feel tired and ask others for help.
Feeling or being sick
Feeling or being sick is usually well controlled with anti sickness medicines. It might help to avoid fatty or fried foods, eat small meals and snacks and take regular sips of water. Relaxation techniques might also help.
It is important to take anti sickness medicines as prescribed even if you don’t feel sick. It is easier to prevent sickness rather than treat it once it has started.
Headaches
Tell your healthcare team if you keep getting headaches. They can give you painkillers to help.
Constipation
is easier to sort out if you treat it early. Drink plenty and eat as much fresh fruit and vegetables as you can. Try to take gentle exercise, such as walking. Tell your healthcare team if you think you are constipated. They can give you a laxative if needed.
Diarrhoea
Contact your advice line if you have diarrhoea. For example, in one day you have 2 or more loose bowel movements than usual. If you have a , you might have more output than normal. Your doctor may give you anti diarrhoea medicine to take home with you after treatment.
Try to eat small meals and snacks regularly. It’s best to try to have a healthy balanced diet if you can. You don’t necessarily need to stop eating foods that contain fibre. But if your diet is normally very high in fibre, it might help to cut back on high fibre foods such as beans, nuts, seeds, dried fruit, bran and raw vegetables.
Drink plenty to try and replace the fluid lost. Aim for 8 to 10 glasses per day.
Loss of appetite
You might lose your appetite for various reasons while having cancer treatment. Sickness, taste changes or tiredness can put you off food and drinks.
Liver changes
You might have liver changes that can cause symptoms such as yellowing of the skin and whites of the eye.
Rarely it can cause your liver to stop working properly. This can cause other symptoms such as confusion, tummy pain and generally feeling unwell.
You have regular blood tests to check for any changes in the way your liver is working.
Breathlessness and coughing
You might develop a cough or breathing problems. Let your doctor or nurse know straight away if you suddenly become breathless or develop a cough.
Sore mouth
Mouth sores and ulcers can be painful. It helps to keep your mouth and teeth clean, drink plenty of fluids and avoid acidic foods such as lemons. Chewing gum can help to keep your mouth moist. Tell your doctor or nurse if you have ulcers.
Fluid build up (oedema)
You may have swelling of your hands and legs due to a build up of fluid (oedema).
Tummy (abdominal) pain
Tell your doctor or nurse if you have this. They can check for the cause of the pain and give you medicine to help.
Joint, back or muscle pain
You might have pain in your back. Less commonly you might also develop joint or muscle pain.
Speak to your doctor or nurse about what painkillers you can take to help with this.
High levels of creatinine in your blood
Your blood tests might show that you have high levels of a substance called creatinine.
Creatinine is a protein made by the muscles. The kidneys remove the creatinine from the body in your urine. High levels of creatinine can be a sign of different things including dehydration or that your kidneys may not be working properly. You have regular blood tests to check the levels of creatinine.
Low levels of albumin
Albumin is an important protein in your body. Low levels of albumin can cause weakness, muscle cramps and swelling in different parts of your body. You have regular blood tests to check the albumin levels.
High levels of substances in the blood
You have a blood test before you have trabectedin. This is to check the blood creatine phosphokinase (CPK) levels. Very high levels of CPK can lead to muscle damage (a condition called rhabdomyolysis), but this is rare. It’s important to let your doctor or nurse know straight away if you have muscle pain or weakness.
High temperature or chills
High temperature (fever, shivering or chills) can happen with this drug. This is because it can affect your body’s ability to control temperature. Having a fever with this drug doesn’t always mean you have an infection. But you should call your advice line, as an infection can be serious if not treated quickly.
Occasional side effects
These side effects happen in between 1 and 10 out of every 100 people (between 1 and 10%). You might have one or more of them. They include:
- sepsis - a serious reaction to an infection. Signs can include feeling very unwell, not passing urine, slurred speech or confusion, breathlessness, mottled or discoloured skin, extreme shivering or muscle pain. Call 999 or go to accident and emergency (A&E) immediately if you have any of these symptoms
- an allergic reaction that can cause a rash, shortness of breath, redness or swelling of the face and dizziness - some allergic reactions can be life threatening, alert your nurse or doctor if notice any of these symptoms
- lack of fluid in the body (dehydration) – signs include feeling dizzy, not passing enough urine and dark coloured urine
- low levels of potassium in the blood - you have regular blood tests to check your levels
- numbness or tingling in fingers or toes (peripheral neuropathy) is often temporary and can improve after you finish treatment
- hair loss
- indigestion - symptoms include heartburn, bloating and burping
- dizziness
- low blood pressure
- episodes of feeling warm and reddening of the skin (flushing)
- skin rash
- taste changes
- weight loss
- difficulty falling asleep or staying asleep (insomnia)
- inflammation around the drip site - rarely the fluid can leak out of the vein into the surrounding tissue. This can cause swelling, redness and discomfort. This could lead to damage of the tissue which may need surgery.
Rare side effects
These side effects happen in fewer than 1 in 100 people (less than 1%). You might have one or more of them. They include:
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leaking of fluid and proteins out of the blood vessels into the tissues. This is called capillary leak syndrome. Tell your doctor if you notice any swelling
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fluid build up on the lungs (pulmonary oedema) - symptoms could include breathlessness and cough
Coping with side effects
We have more information about side effects and tips on how to cope with them.
What else do I need to know?
Other medicines, foods and drink
Cancer drugs can interact with medicines, herbal products, and some food and drinks. We are unable to list all the possible interactions that may happen. An example is grapefruit or grapefruit juice which can increase the side effects of certain drugs.
Tell your healthcare team about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies. Also let them know about any other medical conditions or allergies you may have.
Pregnancy and contraception
This drug may harm a baby developing in the womb. It is important not to become pregnant or get someone pregnant while you are having treatment. Talk to your doctor or nurse about effective contraception before starting treatment.
Women must not become pregnant for at least 3 months after the end of treatment. Men should not get someone pregnant for at least 5 months after treatment.
Loss of fertility
You may not be able to become pregnant or get someone pregnant after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.
Men might be able to store sperm before starting treatment. And women might be able to store eggs or ovarian tissue. But these services are not available in every hospital, so you would need to ask your doctor about this.
Breastfeeding
Don’t breastfeed during this treatment and for 3 months afterwards. This drug may come through into your breast milk.
Treatment for other conditions
If you are having tests or treatment for anything else, always mention your cancer treatment. For example, if you are visiting your dentist.
Immunisations
Don’t have immunisations with live vaccines while you’re having treatment and for up to 12 months afterwards. The length of time depends on the treatment you are having.
Ask your doctor or pharmacist how long you should avoid live vaccinations.
In the UK, live vaccines include rubella, mumps, measles, BCG, and yellow fever.
You can usually have:
- other vaccines, but they might not give you as much protection as usual
- the flu vaccine (as an injection)
- the coronavirus (COVID-19) vaccine
Talk to your doctor or pharmacist about the best time to have a vaccine in relation to your cancer treatment.
Contact with others who have had immunisations
You can be in contact with other people who have had live vaccines as injections. If someone has had a live vaccine by mouth or nasal spray there may be a small risk the vaccine virus can be passed onto you if your is weakened.
Your healthcare team will let you know if you need to take any precautions if you are in close contact with someone who has had a live vaccine.
More information about this treatment
For further information about this treatment and possible side effects go to the electronic Medicines Compendium (eMC) website. You can find the patient information leaflet on this website.
You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.