What is pancreatic cancer?
The pancreas is a gland that produces digestive juices and hormones. Pancreatic cancer is when abnormal cells in the pancreas start to divide and grow in an uncontrolled way and forms a growth (tumour).
The cancer cells can grow into surrounding blood vessels or organs such as the small bowel (duodenum). And may spread to other areas of the body.
The pancreas
The pancreas is part of the digestive system.
The pancreas is quite high up in your abdomen. It lies across your body where your ribs meet at the bottom of your breastbone, just behind your stomach. It is about 6 inches (15 centimetres) long and shaped like a leaf.
The pancreas has 3 parts:
- the wide end is called the head
- the thin end is called the tail
- the bit in the middle is called the body
The pancreas is a large gland that makes digestive juices and hormones, including insulin. The digestive juices flow down a tube (pancreatic duct) into the duodenum. The duodenum is the first part of the small bowel and is joined to the stomach.
Another tube (duct) joins the duodenum. The bile duct comes down from the gallbladder and liver and joins the duodenum right next to the pancreatic duct. The place where the two ducts join and meet the bowel is called the ampulla of Vater.
Watch this 2 minute video to explain what the pancreas is.
The pancreas is a leaf shaped organ tucked under the liver, close to the gallbladder, stomach and bowel.
It is part of both the digestive and endocrine systems.
The pancreas lies across your body just behind your stomach. It is about 15 centimetres long.
The pancreas has three parts.
The wide end is called the head.
The middle is called the body.
The thin end is called the tail.
The pancreas is a large gland. It makes hormones which regulate the level of sugar in your blood. One of these hormones is Insulin. This is the endocrine function of the pancreas.
The pancreas also makes digestive juices
The juices flow down a tube called the pancreatic duct into the first part of the small bowel.
The bile duct joins the small bowel right next to the pancreatic duct.
The place where the 2 ducts join and meet the bowel is called the ampulla of Vater.
Digestive juices contain enzymes that help you to break down food in the bowel.
This is called the exocrine function of the pancreas.
Cancer that starts in the cells that make digestive juices is called exocrine pancreatic cancer. This is the most common type of pancreatic cancer.
Cancers that start in the cells that make insulin and other hormones, are called endocrine pancreatic cancers or Pancreatic neuroendocrine tumours.
Close to the pancreas there are lymph nodes that are part of our immune system and help us fight infections.
Lymph nodes are often the first place cancer cells reach when they break away from a tumour.
For information about pancreatic cancer go to cruk.org/cancer-types
What does the pancreas do?
The pancreas produces digestive juices and insulin, as well as other hormones to do with digestion.
The part which produces the digestive juices is called the exocrine pancreas. The part which produces hormones, including insulin, is called the endocrine pancreas.
Cancers that develop from these two parts can behave differently and cause different symptoms.
What does the digestive system do?
The digestive system breaks up and digests food. After about 2 hours in the stomach, the partly digested food moves into the beginning of the duodenum.
When the food reaches the duodenum, the pancreas releases its digestive juices which flow down the pancreatic duct and mix with the food.
The juices contain enzymes that help to break down the food into very small fragments. These fragments are absorbed into the body through the small bowel.
The pancreas and insulin
The pancreas makes insulin. Specialised cells within the pancreas releases insulin directly into the bloodstream.
Insulin keeps the level of sugar (glucose) in the blood at a stable level. This means that the body cells get enough sugar, but not too much. The pancreas makes and releases more insulin if the level of sugar in the blood is high. If the level is too low, it releases less.
You have a condition called diabetes if you don't make enough insulin.
How common is pancreatic cancer?
Around 10,500 people are diagnosed with pancreatic cancer in the UK each year. It is the 10th most common cancer in the UK.
Who gets pancreatic cancer?
Pancreatic cancer is more common in older people. More than 45 out of 100 people diagnosed (more than 45%) are aged 75 and over. Pancreatic cancer is uncommon in people under 40 years old.
In England, pancreatic cancer is more common in people living in more deprived areas. It is more common in White and Black people than in Asian people and in people of mixed or multiple ethnicity.
