About the staging of liver cancer

The stage of primary Open a glossary item liver cancer tells you how big it is and whether it has spread to other parts of the body. This helps your doctor recommend the best treatment for you. You have tests after being diagnosed to help stage your cancer.

Primary liver cancer is different to cancer that spreads to your liver from somewhere else in your body. This is called secondary liver cancer or liver metastases.

Staging systems for liver cancer

There are different staging systems your doctor can use for hepatocellular carcinoma (HCC) Open a glossary item:

  • BCLC strategy and Child-Pugh system
  • TNM staging system
  • number staging system

BCLC strategy and Child-Pugh system

Doctors often use the Barcelona Clinic Liver Cancer (BCLC) staging system to help make treatment decisions for HCC. This system looks at the number and size of liver tumours, as well as how well your liver is working, your general health and your cancer related symptoms.

When deciding on treatment your doctor has to think about how well your liver is working. This is especially the case if you have liver damage (cirrhosis). Doctors use the Child-Pugh system and other blood tests and scans to score how well your liver is working. Unfortunately, people with severe liver damage may be too unwell to have treatment for their cancer.

TNM staging

The TNM staging system stands for tumour, node and metastases.

  • T describes the size of the tumour (cancer) and if there is more than one tumour in the liver
  • N describes whether there are any cancer cells in the lymph nodes Open a glossary item
  • M describes whether the cancer has spread to a different part of the body

Your doctor gives each letter (T, N and M) a number, depending on how far the cancer has grown.

The tests and scans you have to diagnose your cancer give some information about the stage. But your doctor may not be able to tell you the exact stage until after your surgery, if you are able to have it.  

Number staging system

The number staging system divides liver cancer into 4 main stages, from 1 to 4. Stage 1 is an early cancer. Stage 4 is advanced, which means the cancer has spread to the lymph nodes or another part of the body.

Whether your cancer can be removed with surgery

Your doctor might also classify liver cancer depending on whether they can remove it (resectable) or not (unresectable).

Surgery to remove cancer that is only in the liver includes removing part of the liver (resection) or a liver transplant. If you can’t have surgery, you may have other treatments to help control the cancer.

  • AJCC Cancer Staging Manual, 8th edition
    American Joint Committee on Cancer
    Springer, 2017

  • British Society of Gastroenterology guidelines for the management of hepatocellular carcinoma in adults
    A Suddle and others
    Gut, 2024. Volume 0. Pages 1-34

  • BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update
    M Reig and others
    Journal of Hepatology, 2022. Volume 76. Pages 681-693

  • EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma
    European Association for the Study of the Liver
    Journal of Hepatology, 2025. Volume 82. Pages 315-374

  • Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow up
    A Vogel and others
    Annals of Oncology, 2025

  • The information on this page is based on literature searches and specialist checking. We used many references and there are too many to list here. Please contact patientinformation@cancer.org.uk if you would like to see the full list of references we used for this information.

Last reviewed: 
25 Mar 2025
Next review due: 
24 Mar 2028

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